ROLE OF GONADAL-HORMONES IN HYPERTENSION IN THE DAHL SALT-SENSITIVE RAT

被引:91
作者
ROWLAND, NE [1 ]
FREGLY, MJ [1 ]
机构
[1] UNIV FLORIDA,DEPT PHYSIOL,GAINESVILLE,FL 32611
关键词
D O I
10.3109/10641969209036195
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The present studies examine the effect of gonadal hormones on the development of hypertension in Dahl salt-sensitive rats fed a high salt diet. In the first study, administration of estradiol benzoate did not prevent hypertension in either adult ovariectomized females or intact males. In a second study, neonatal castration of males slowed the onset of salt-induced hypertension, and females that were treated neonatally with testosterone developed somewhat higher pressures that did untreated females. These data extend to Dahl S rats the findings observed originally in spontaneously hypertensive rats that blood pressure is modulated by gonadal hormones. These results are consistent with the conclusion that gonadal hormones may exert organizational effects on cardiovascular control regions of the brain during early postnatal development in rats.
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页码:367 / 375
页数:9
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