THE EFFECT OF NAFTIDROFURYL ON RED-BLOOD-CELL AGGREGATION DETECTED INVITRO WITH ULTRASOUND

被引：5

作者：

ALANEN, A ^{[1
]}

KALLIO, T ^{[1
]}

LEHTO, I ^{[1
]}

WIERNSPERGER, N ^{[1
]}

机构：

[1] LIPHA,DEPT INT PHARMACOL,DIV INT,LYONS,FRANCE

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1990年 / 16卷

关键词：

NAFTIDROFURYL; RED BLOOD CELL AGGREGATION; BLOOD ECHOGENICITY;

D O I：

10.1097/00005344-199006163-00008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Red blood cell aggregates are mainly responsible for the echogenicity of flowing blood. Thus, ultrasound can be used to observe the degree of red blood cell aggregation in slow flow conditions. We quantified blood echogenicity to study aggregation tendency of red blood cells in blood of patients with claudication, patients with suspected venous thrombosis, and normal volunteers without and with in vitro addition of naftidrofuryl (10(-6) M). Normal volunteers showed lower original echogenicity than any group of patients, and claudication patients showed the highest echogenicity. Naftidrofuryl caused a fall in mean echogenicity in all groups, and its effect was pronounced on blood samples with a high original echogenicity.

引用

页码：S33 / S35

页数：3

共 12 条

[1] NAFTIDROFURYL IN CHRONIC ARTERIAL-DISEASE RESULTS OF A 6 MONTH CONTROLLED MULTICENTER STUDY USING NAFTIDROFURYL TABLETS 200-MG [J].