DISTRIBUTIONS OF NEUROPEPTIDE-Y, VASOACTIVE-INTESTINAL-PEPTIDE AND SOMATOSTATIN IN POPULATIONS OF POSTGANGLIONIC NEURONS INNERVATING THE RAT-KIDNEY, SPLEEN AND INTESTINE

被引:35
作者
CHEVENDRA, V
WEAVER, LC
机构
[1] JOHN P ROBARTS RES INST, 100 PERTH DR, POB 5015, LONDON N6A 5K8, ONTARIO, CANADA
[2] UNIV WESTERN ONTARIO, HLTH SCI CTR, DEPT PHYSIOL, LONDON N6A 5C1, ONTARIO, CANADA
关键词
D O I
10.1016/0306-4522(92)90460-J
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Some peripheral peptidergic nerves selectively innervate different types Of tissue in abdominal organs' Neuropeptide Y- and vasoactive intestinal peptide-immunoreactive nerve terminals have been identified in the kidney, spleen and intestine and these peptides may have important physiological actions. Somatostatin has been found in sympathetic ganglia, and nerve terminals containing this peptide have been identified in the intestine. We have used fluorescent retrograde tracers to identify renal, splenic and mesenteric postganglionic neurons in rat sympathetic ganglia and then used immunocytochemistry to determine the proportions of these three identified groups of neurons displaying immunoreactivity for neuropeptide Y, vasoactive intestinal peptide and somatostatin. Most renal, splenic and mesenteric neurons were immunoreactive for neuropeptide Y and less than 1 % of cells innervating these organs were immunoreactive for vasoactive intestinal peptide. Somatostatin immunoreactivity was present only in a small percentage of mesenteric neurons and not in renal or splenic neurons. The present study demonstrates that (i) the rat kidney, spleen and intestine do not differ in the proportion of innervation by neuropeptide Y-immunoreactive neurons, (ii) the solar plexus, splanchnic ganglion and chain ganglia (T12 and T13) provide very little vasoactive intestinal peptide-immunoreactive inputs to these organs, and (iii) somatostatin-immunoreactive neurons innervate the intestine but not the kidney or spleen.
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页码:727 / 743
页数:17
相关论文
共 51 条
[1]   SYMPATHETIC-NERVE STIMULATION VERSUS PANCREATIC NOREPINEPHRINE INFUSION IN THE DOG .2. EFFECTS ON BASAL RELEASE OF SOMATOSTATIN AND PANCREATIC-POLYPEPTIDE [J].
AHREN, B ;
VEITH, RC ;
PAQUETTE, TL ;
TABORSKY, GJ .
ENDOCRINOLOGY, 1987, 121 (01) :332-339
[2]   NEUROPEPTIDE-Y - A NOVEL RENAL PEPTIDE WITH VASOCONSTRICTOR AND NATRIURETIC ACTIVITY [J].
ALLEN, JM ;
RAINE, AEG ;
LEDINGHAM, JGG ;
BLOOM, SR .
CLINICAL SCIENCE, 1985, 68 (04) :373-377
[3]  
BALLESTA J, 1984, HISTOCHEMISTRY, V80, P483, DOI 10.1007/BF00495438
[4]   VASOACTIVE INTESTINAL POLYPEPTIDE-IMMUNOREACTIVE NERVES IN THE KIDNEY [J].
BARAJAS, L ;
SOKOLSKI, KN ;
LECHAGO, J .
NEUROSCIENCE LETTERS, 1983, 43 (2-3) :263-269
[5]  
BENOIT R, 1985, SOMATOSTATIN, P89
[6]   IDENTIFICATION OF HUMAN MONONUCLEAR LEUKOCYTES BEARING RECEPTORS FOR SOMATOSTATIN AND GLUCAGON [J].
BHATHENA, SJ ;
LOUIE, J ;
SCHECHTER, GP ;
REDMAN, RS ;
WAHL, L ;
RECANT, L .
DIABETES, 1981, 30 (02) :127-131
[7]  
CASSELL JF, 1990, J PHYSIOL-LONDON, V327, P457
[8]   DISTRIBUTION OF SPLENIC, MESENTERIC AND RENAL NEURONS IN SYMPATHETIC-GANGLIA IN RATS [J].
CHEVENDRA, V ;
WEAVER, LC .
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1991, 33 (01) :47-54
[9]   CHEMICAL CODING OF ENTERIC NEURONS [J].
COSTA, M ;
FURNESS, JB ;
GIBBINS, IL .
PROGRESS IN BRAIN RESEARCH, 1986, 68 :217-239
[10]   SOMATOSTATIN IS PRESENT IN A SUBPOPULATION OF NORADRENERGIC NERVE-FIBERS SUPPLYING THE INTESTINE [J].
COSTA, M ;
FURNESS, JB .
NEUROSCIENCE, 1984, 13 (03) :911-919