IN-VIVO ACTIVITY OF AJOENE AGAINST RODENT MALARIA

被引：45

作者：

PEREZ, HA ^{[1
]}

DELAROSA, M ^{[1
]}

APITZ, R ^{[1
]}

机构：

[1] INST VENEZOLANO INVEST CIENT,CTR BIOFIS & BIOQUIM,CARACAS,VENEZUELA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 02期

关键词：

D O I：

10.1128/AAC.38.2.337

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ajoene (4,5,9-trithiadodeca-1,6,11-triene 9-oxide), a product initially isolated from extracts of garlic (Allium sativum), was tested for its antimalarial activity in vivo in a well-characterized murine model. A single ajoene dose of 50 mg/kg, on the day of infection, suppressed the development of parasitemia; there were no obvious acute toxic effects from the tested dose. The combination of ajoene (50 mg/kg) and chloroquine (4.5 mg/kg), given as a single dose on the day of the infection, completely prevented the subsequent development of parasitemia in treated mice.

引用

页码：337 / 339

页数：3

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