ANALOGS OF THE MARINE NATURAL PRODUCT SCALARADIAL LACKING THE ALPHA,BETA-UNSATURATED ALDEHYDE - EFFECTS ON HUMAN SYNOVIAL-FLUID PHOSPHOLIPASE A(2) AND MACROPHAGE LIPID MEDIATOR PRODUCTION

被引：8

作者：

GLASER, KB

SUNG, ML

LOCK, YW

BAUER, J

KUBRAK, D

KREFT, A

机构：

[1] Inflammatory Diseases and Medicinal Chemistry, Wyeth-Ayerst Research, Princeton, NJ 08543

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(01)80388-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The role of the alpha,beta-unsaturated aldehyde in the inhibition of PLA(2) by scalaradial was investigated by reduction to the triol and oxidation to the diacid. The results demonstrate that the reactivity of the alpha,beta-unsaturated aldehyde of scalaradial is not absolutely essential to its ability to inhibit PLA(2) and lipid mediator production in the intact cell but adds significantly to its inhibitory potency.

引用

页码：1873 / 1878

页数：6

共 11 条

[1]

CIMINO G, 1974, EXPERIENTIA, V30, P846

[2] 2-STEP INACTIVATION OF BEE VENOM PHOSPHOLIPASE-A2 BY SCALARADIAL [J].