STARCH INTAKE AND COLORECTAL-CANCER RISK - AN INTERNATIONAL COMPARISON

被引:260
作者
CASSIDY, A
BINGHAM, SA
CUMMINGS, JH
机构
[1] Medical Research Council, Dunn Clinical Nutrition Centre
关键词
D O I
10.1038/bjc.1994.181
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Intakes of starch, non-starch polysaccharides (NSPs), protein and fat have been compared with colorectal cancer incidence in 12 populations worldwide. There were strong inverse associations between starch consumption and large bowel cancer incidence (large bowel r = -0.70, colon r = -0.76). There was no significant relation with NSPs, although the association with large bowel cancer incidence was still significant when NSP was combined with resistant starch (RS) to give an estimate of fermentable carbohydrate (large bowel r = -0.52, colon r = -0.60). The relationships between starch, RS and NSPs and cancer incidence remained statistically significant after adjusting for fat and protein intakes. The strong inverse associations found here suggest a potentially important role for starch in protection against colorectal cancer and correspond with the hypothesis that fermentation in the colon is the mechanism for preventing colorectal cancer. Measures of both starch and NSPs need to be included in future epidemiological studies of diet and bowel cancer.
引用
收藏
页码:937 / 942
页数:6
相关论文
共 51 条
[1]   ENVIRONMENTAL FACTORS AND CANCER INCIDENCE AND MORTALITY IN DIFFERENT COUNTRIES, WITH SPECIAL REFERENCE TO DIETARY PRACTICES [J].
ARMSTRONG, B ;
DOLL, R .
INTERNATIONAL JOURNAL OF CANCER, 1975, 15 (04) :617-631
[2]   DIETARY FIBER AND REGIONAL LARGE-BOWEL CANCER MORTALITY IN BRITAIN [J].
BINGHAM, S ;
WILLIAMS, DRR ;
COLE, TJ ;
JAMES, WPT .
BRITISH JOURNAL OF CANCER, 1979, 40 (03) :456-463
[3]  
BINGHAM S A, 1990, Journal of Human Nutrition and Dietetics, V3, P333, DOI 10.1111/j.1365-277X.1990.tb00244.x
[4]   DIETARY FIBER CONSUMPTION IN BRITAIN - NEW ESTIMATES AND THEIR RELATION TO LARGE BOWEL-CANCER MORTALITY [J].
BINGHAM, SA ;
WILLIAMS, DRR ;
CUMMINGS, JH .
BRITISH JOURNAL OF CANCER, 1985, 52 (03) :399-402
[6]  
BOFFA LC, 1992, CANCER RES, V52, P5906
[7]   ESTIMATION OF THE AMOUNT OF DIETARY STARCH AVAILABLE TO DIFFERENT POPULATIONS [J].
BRIGHTSEE, E ;
JAZMAJI, V .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1991, 69 (01) :56-59
[8]  
CADERNI G, 1989, CANCER RES, V49, P1655
[9]  
CALKINS B M, 1984, American Journal of Clinical Nutrition, V40, P896
[10]  
CUMMINGS J H, 1992, Gastroenterology, V102, pA548