PRESENCE OF BOTH A(1) AND A(2A) ADENOSINE RECEPTORS IN HUMAN-CELLS AND THEIR INTERACTION

被引：14

作者：

AHMED, AH ^{[1
]}

JACOBSON, KA ^{[1
]}

KIM, JH ^{[1
]}

HEPPEL, LA ^{[1
]}

机构：

[1] NIDDK,CHEM LAB,BETHESDA,MD 20892

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 208卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.1416

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have obtained pharmacological evidence for the expression of both A(1)- (inhibitory) and A(2a)- (stimulatory) adenosine receptors in cultured human foreskin fibroblasts and lung fibroblasts. The Al receptors were sufficiently abundant in foreskin fibroblasts so that binding studies with a radioactively labeled specific ligand confirmed their existence. Both receptors were activated during the stimulation of cAMP accumulation and DNA synthesis by adenosine. (C) 1995 Academic Press, Inc.

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页码：871 / 878

页数：8

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