RELATIONSHIPS AMONG IN-VITRO MUTAGENICITY ASSAYS - QUANTITATIVE VS QUALITATIVE TEST-RESULTS

被引：6

作者：

BENIGNI, R ^{[1
]}

ANDREOLI, C ^{[1
]}

GIULIANI, A ^{[1
]}

机构：

[1] INST RES SENESCENCE,POMEZIA,ITALY

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1995年 / 26卷 / 02期

关键词：

IN VITRO GENOTOXICITY TESTS; MUTAGENICITY; MULTIVARIATE DATA ANALYSIS; QUALITATIVE; QUANTITATIVE; PRINCIPAL COMPONENT ANALYSIS;

D O I：

10.1002/em.2850260209

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In previous investigations, we studied the relationships between the profiles of the qualitative responses of in vitro short-term tests (mutation in Salmonella typhimurium, chromosomal aberrations in CHO cells, sister chromatid exchanges in CHO and mutation in mouse lymphoma cells) and common sets of chemicals. In this paper, we address the study of the quantitative responses (potency). We show that two analyses point to similar patterns of relationships: the mutation in mouse lymphoma cells assay is most similar to the CHO sister chromatid exchange assay, and the Salmonella assay is most similar to the CHO chromosomal aberrations assay. (C) 1995 Wiley-Liss, Inc.

引用

页码：155 / 162

页数：8

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