EFFECTS OF FATTY-ACIDS ON PROLIFERATION AND ACTIVATION OF HUMAN SYNOVIAL COMPARTMENT LYMPHOCYTES

被引：24

作者：

DEMARCO, DM ^{[1
]}

SANTOLI, D ^{[1
]}

ZURIER, RB ^{[1
]}

机构：

[1] HOSP UNIV PENN,WISTAR INST ANAT & BIOL,DEPT MED,DIV RHEUMATOL,PHILADELPHIA,PA 19104

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1994年 / 56卷 / 05期

关键词：

RHEUMATOID ARTHRITIS; FATTY ACIDS; T CELLS;

D O I：

10.1002/jlb.56.5.612

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The object of this study was to determine the effects of eicosanoid precursor fatty acids on activation and proliferation of T lymphocytes from synovial fluid and synovial tissue of rheumatoid arthritis patients. Proliferation was determined by direct cell counts; phenotypic characterization of surface molecules was by cytofluorometric analysis. Dihomogammalinolenic acid, arachidonic acid, and eicosapentaenoic acid suppressed proliferation of interleukin-2-dependent lymphocytes by as much as 80%; cell viability was not altered by fatty acids. Administration of particular fatty acids may prove to be a useful therapeutic intervention in rheumatoid arthritis patients because of their ability to suppress activation and proliferation of synovial compartment T lymphocytes.

引用

页码：612 / 615

页数：4

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