A BABOON (PAPIO-HAMADRYAS) MODEL OF INSULIN-DEPENDENT DIABETES

被引：18

作者：

HEFFERNAN, S

PHIPPARD, A

SINCLAIR, A

MCLENNAN, S

HENNESSY, A

GILLIN, A

HORVATH, J

TILLER, D

YUE, D

TURTLE, J

机构：

[1] ROYAL PRINCE ALFRED HOSP,DEPT ENDOCRINOL,CAMPERDOWN 2050,NSW,AUSTRALIA

[2] ROYAL PRINCE ALFRED HOSP,DEPT RENAL MED,CAMPERDOWN 2050,NSW,AUSTRALIA

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1995年 / 24卷 / 01期

关键词：

DIABETES; BABOONS; COMPLICATIONS; HBA1C;

D O I：

10.1111/j.1600-0684.1995.tb00141.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Over a period of four years, streptozocin has been used to induce diabetes in 10 baboons, all of whom are insulin dependent. We describe our experience with their husbandry, induction of diabetes, insulin therapy, metabolic control and growth rate. Streptozocin dosage of 60 mg/kg readily induces hyperglycemia with minimal hepatic or renal toxicity. Using a once daily injection of mixed short and intermediate acting insulins at a dosage of 2-4 U/kg, it is possible to maintain a degree of metabolic control similar to that attained in patients.

引用

页码：29 / 34

页数：6

共 16 条

[1] COMPARISON OF HEMOGLOBIN-A1C IN HUMAN AND BABOON BLOOD [J].