HUMAN OLFACTORY RECEPTOR NEURONS EXPRESS HEAT-SHOCK PROTEIN-70 - AGE-RELATED TRENDS

被引：37

作者：

GETCHELL, TV

KRISHNA, NSR

SPARKS, DL

DHOOPER, N

GETCHELL, ML

机构：

[1] UNIV KENTUCKY,COLL MED,DEPT SURG,DIV OTOLARYNGOL HEAD & NECK SURG,LEXINGTON,KY 40536

[2] UNIV KENTUCKY,COLL MED,DEPT PHYSIOL,LEXINGTON,KY 40536

[3] UNIV KENTUCKY,COLL MED,DEPT PATHOL,MED EXAMINER PROGRAM,LEXINGTON,KY 40536

[4] UNIV KENTUCKY,COLL MED,SANDERS BROWN CTR AGING,LEXINGTON,KY 40536

来源：

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY | 1995年 / 104卷 / 01期

关键词：

ALZHEIMERS DISEASE; BOWMANS GLANDS; HEAT SHOCK PROTEIN 70; NASAL MUCOSA; OLFACTORY MUCOSA; RESPIRATORY MUCOSA;

D O I：

10.1177/000348949510400108

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Immunocytochemical methods were used to investigate the cellular distribution and age-related trends in the expression of constitutive and/or inducible forms of heat shock protein (hsp) 70 in the human nasal mucosa of 22 subjects who ranged in age from 16 weeks prenatal to 90 years, including 3 subjects with Alzheimer's disease. The olfactory mucosa was characterized by the presence of olfactory marker protein-immunoreactive olfactory receptor neurons. The hsp 70 immunoreactivity was localized in olfactory receptor neurons and the supranuclear region of sustentacular cells in the olfactory epithelium, and in the acinar cells of the Bowman's glands in the lamina propria. A systematic age-related decrement in the expression of hsp 70 immunoreactivity was observed in the olfactory receptor neurons. This trend was not apparent in sustentacular cells and Bowman's glands. A marked decrement in hsp 70 immunoreactivity was also noted in the olfactory receptor neurons of subjects with Alzheimer's disease when compared to age-matched controls. These results suggest that the age-dependent decrease in hsp 70 in olfactory receptor neurons of older subjects and those with Alzheimer's disease may be attributable to their greater susceptibility to stress.

引用

页码：47 / 56

页数：10

共 37 条

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