IDENTIFICATION OF SUGAR DEGRADATION INTERMEDIATES IN A METALLOPORPHYRIN-MEDIATED DNA CLEAVAGE RESULTING FROM HYDROXYLATION AT C-5

被引：17

作者：

PRATVIEL, G

PITIE, M

PERIGAUD, C

GOSSELIN, G

BERNADOU, J

MEUNIER, B

机构：

[1] UNIV MONTPELLIER 2,CNRS,UMR 112,CHIM BIOORGAN LAB,PL EUGENE BATAILLON,F-34095 MONTPELLIER 05,FRANCE

[2] CNRS,CHIM COORDINAT LAB,F-31077 TOULOUSE,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 02期

关键词：

D O I：

10.1039/c39930000149

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydroxylation of poly(dA).poly(dT) at the 5' position of the deoxyribose units by the chemical nuclease Mn-TMPyP-KHSO5 [Mn-TMPyP = manganese(III) complex of meso-tetrakis(4-N-methylpyridiniumyl)porphyrin] followed by an additional thermal step provides 5'-aldehyde-3',4'-unsaturated nucleosides which can be reduced by sodium borohydride and then hydrogenated with palladium on charcoal giving 2',3'-dideoxyribonucleosides having the natural beta or the non-natural alpha configuration at 4'.

引用

页码：149 / 151

页数：3

共 14 条

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