VISCOSIMETRIC INVESTIGATION OF THE INTERACTION BETWEEN SODIUM DODECYL-SULFATE MICELLES AND A POLYMER DRUG CARRIER

The viscosities of aqueous sodium dodecyl sulfate solutions with and without alpha,beta-poly(N-hydroxyethyl)-DL-aspartamide (PHEA), at 15, 25 and 35-degrees-C are reported. The viscosities of SDS and of PHEA aqueous solutions are discussed in terms of the parameter D [D = (eta/eta0 - 1)/phi] describing the non-ideal behavior of SDS micelles and of PHEA macromolecules. The viscosities of SDS plus PHEA aqueous solutions, discussed in terms of the parameter F [F = eta(rel)(PHEA) + eta(rel)(SDS) - eta(rel)(SDS + PHEA)], demonstrate the occurrence of interactions between SDS micelles and the PHEA macromolecule. Both D and F are scarcely influenced by temperature variation.