PULSATILE GROWTH-HORMONE RELEASE IN TURNERS SYNDROME AND SHORT NORMAL-CHILDREN

被引:12
作者
GHIZZONI, L
LAMBORGHINI, A
ZIVERI, M
VOLTA, C
PANZA, C
BALESTRAZZI, P
BERNASCONI, S
机构
[1] Department of Pediatrics, University of Parma, I-43100 Parma
来源
ACTA ENDOCRINOLOGICA | 1990年 / 123卷 / 03期
关键词
D O I
10.1530/acta.0.1230291
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To determine whether the quantitative and qualitative aspects of GH secretion in girls with Turner's syndrome are similar to those of short-normal children we studied the 24-h GH secretion of 10 patients with Turner's syndrome and 9 short-normal children with comparable auxological features. GH profiles, obtained by 30-min sampling, were analysed by the Pulsar programme. The pulsatile GH release over the 24 h in Turner's syndrome was similar to that in normal children. However, when the GH release over the 12 day and night hours were separately analysed, only normal children showed a night-time increase in the sum of peak amplitudes. Moreover, patients with Turner's syndrome had significantly decreased number and frequency of peaks in the night-time compared with short children. In short-normal children but not in Turner's syndrome, height velocity was related to the 24-h integrated concentration of GH, area under the curve over zero-line and over base-line, sum of peak areas, and amplitudes. Night-time GH area over zero-line and over baseline, mean peak amplitude, height, area, sum of peak areas, and amplitudes were positively correlated with height velocity in short children, whereas in Turner's syndrome height velocity was related to daytime parameters only. In conclusion, girls with Turner's syndrome have a discrete pattern of pulsatile GH release. However, the relation of GH secretion to growth, in these patients, is uncertain.
引用
收藏
页码:291 / 297
页数:7
相关论文
共 15 条
[1]   ANALYSES OF 24-HOUR GROWTH-HORMONE PROFILES IN CHILDREN - RELATION TO GROWTH [J].
ALBERTSSONWIKLAND, K ;
ROSBERG, S .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 67 (03) :493-500
[2]  
[Anonymous], 1959, RADIOGRAPH ATLAS SKE
[3]   SAVING SOCIOBIOLOGY - THE USE AND ABUSE OF LOGIC [J].
BERNSTEIN, IS .
BEHAVIORAL AND BRAIN SCIENCES, 1987, 10 (01) :73-73
[4]   GROWTH-HORMONE RESPONSE TO GROWTH-HORMONE RELEASING HORMONE 1-40 IN TURNERS SYNDROME [J].
CAPPA, M ;
LOCHE, S ;
BORRELLI, P ;
CORDA, R ;
MARINI, R ;
PORCEDDA, C ;
PINTOR, C .
HORMONE RESEARCH, 1987, 27 (01) :1-6
[5]   TRANSIENT PARTIAL HGH DEFICIENCY IN PREPUBERTAL CHILDREN WITH DELAY OF GROWTH [J].
GOURMELEN, M ;
PHAMHUUTRUNG, MT ;
GIRARD, F .
PEDIATRIC RESEARCH, 1979, 13 (04) :221-224
[6]   THE RELATIONSHIP BETWEEN HEIGHT VELOCITY AND GROWTH-HORMONE SECRETION IN SHORT PREPUBERTAL CHILDREN [J].
HINDMARSH, P ;
SMITH, PJ ;
BROOK, CGD ;
MATTHEWS, DR .
CLINICAL ENDOCRINOLOGY, 1987, 27 (05) :581-591
[7]   DETERMINATION OF INTEGRATED PLASMA CONCENTRATIONS AND TRUE SECRETION RATES OF HUMAN GROWTH HORMONE [J].
KOWARSKI, A ;
THOMPSON, RG ;
MIGEON, CJ ;
BLIZZARD, RM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1971, 32 (03) :356-+
[8]   GROWTH-HORMONE RESERVE CAPACITY IN TURNERS SYNDROME [J].
LACZI, F ;
JULESZ, J ;
JANAKY, T ;
LASZLO, FA .
HORMONE AND METABOLIC RESEARCH, 1979, 11 (12) :664-666
[9]   GROWTH-HORMONE SECRETION IN TURNERS SYNDROME AND INFLUENCE OF OXANDROLONE AND ETHINYL ESTRADIOL [J].
MASSARANO, AA ;
BROOK, CGD ;
HINDMARSH, PC ;
PRINGLE, PJ ;
TEALE, JD ;
STANHOPE, R ;
PREECE, MA .
ARCHIVES OF DISEASE IN CHILDHOOD, 1989, 64 (04) :587-592
[10]  
MERRIAM GR, 1982, AM J PHYSIOL-ENDOC M, V243, P310