N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS AND CHANNEL BLOCKERS HAVE DIFFERENT EFFECTS UPON A SPINAL SEIZURE MODEL IN MICE

被引：16

作者：

MCALLISTER, KH

机构：

[1] Sandoz Research Institute Berne Ltd., CH-3001 Berne, Monbijoustrasse 115

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 211卷 / 01期

关键词：

STRYCHNINE; HANDLING; SEIZURES; NMDA RECEPTOR ANTAGONISTS; (MOUSE);

D O I：

10.1016/0014-2999(92)90269-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Spinal seizures in mice induced by handling following pretreatment with a subconvulsive dose of strychnine could be blocked by competitive N-methyl-D-aspartate (NMDA) receptor antagonists (D-, L-, DL-CPPene (CPPene = (E)-4-(3)-phophonoprop-2-enyl)-piperazine-2-carboxylic acid), D-AP5 (D-2-amino-5-phophonovalerate)) and compounds acting at receptor-coupled modulatory sites (R-HA 966, ifenprodil). NMDA cation channel antagonists (MK-801, phencyclidine) however, resulted in ataxia, tremor and loss of righting. There are differences between NMDA antagonists acting via the receptor and the cation channel in this model of spinal seizure.

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页码：105 / 108

页数：4

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