SALMONELLA AND MAMMALIAN-CELL MUTAGENICITY OF 3-CHLORO-4-(CHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE

被引：8

作者：

NIITTYKOSKI, M ^{[1
]}

HYTTINEN, JMT ^{[1
]}

JANSSON, K ^{[1
]}

机构：

[1] NATL PUBL HLTH INST,DEPT ENVIRONM HLTH,SF-70701 KUOPIO,FINLAND

来源：

MUTATION RESEARCH LETTERS | 1995年 / 348卷 / 01期

关键词：

CHLOROHYDROXYFURANONE; DRINKING WATER; MUTAGENICITY TEST; SALMONELLA/HIS; CHO/HPRT;

D O I：

10.1016/0165-7992(95)90021-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

3-Chloro-4-(chloromethyl)-5-hydroxy-2(5H)-furanone (CMCF), a chlorine disinfection by-product in drinking water, was mutagenic in the Salmonella/his (Ames) assay for both base-pair substitution strains (TA1535, TA100, TA102) and frameshift strains (TA97, TA98) with the highest mutagenic response observed in strain TA100 (1292 revertants/mu g). The presence in TA100 of pKM101 plasmid, which enhances error-phone DNA repair, greatly increased susceptibility to CMCF mutagenicity relative to the isogenic strain TA1535 lacking pKM101. In the Chinese hamster ovary (CHO) cell hprt (6-thioguanine resistance) locus assay, the mutagenicity of CMCF (1.04 mutants/10(6) clonable cells per mu g/ml) was barely detectable because of the low mutagenicity/cytotoxicity ratio. From the present experiments it appears that CMCF acts in a manner similar to that of another drinking water mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX). However, CMFC appears to be a less potent mutagen in vitro than MX.

引用

页码：51 / 55

页数：5

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