NITRIC-OXIDE IS INVOLVED IN HEAT-INDUCED HSP70 ACCUMULATION

被引：87

作者：

MALYSHEV, IY ^{[1
]}

MANUKHINA, EB ^{[1
]}

MIKOYAN, VD ^{[1
]}

KUBRINA, LN ^{[1
]}

VANIN, AF ^{[1
]}

机构：

[1] INST CHEM PHYS,MOSCOW 117977,RUSSIA

来源：

FEBS LETTERS | 1995年 / 370卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

HEAT SHOCK; EPR; WESTERN BLOT ANALYSIS; NITRIC OXIDE; STRESS PROTEIN;

D O I：

10.1016/0014-5793(95)00801-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heat shock potentiated the nitric oxide production (EPR assay) in the liver, kidney, heart, spleen, intestine, and brain. The heat shock-induced sharp transient increase in the rate of nitric oxide production preceded the accumulation of heat shock proteins (HSP70) (Western blot analysis) as measured in the heart and liver, In all organs the nitric oxide formation,vas completely blocked by the NO-synthase inhibitor N-omega-nitro-L-arginine (L-NNA), L-NNA also markedly attenuated the heat shock-induced accumulation of HSP70, The results suggests that nitric oxide is involved in the heat shock-induced activation of HSP70 synthesis.

引用

页码：159 / 162

页数：4

共 27 条

[1]

BERBERIAN PA, 1990, AM J PATHOL, V136, P71

[2] NITRIC-OXIDE - A PHYSIOLOGICAL MESSENGER MOLECULE [J].