IMPROVED SENSITIVITY IN CARIES CLINICAL-TRIALS BY SELECTION ON THE BASIS OF BASE-LINE CARIES EXPERIENCE

被引:4
作者
BURCHELL, CK
STEPHEN, KW
SCHAFER, F
HUNTINGTON, E
机构
[1] UNIV GLASGOW,SEKT DENT,378 SAUCHIEHALL ST,GLASGOW G12 8QQ,SCOTLAND
[2] UNILEVER DENT RES,PORT SUNLIGHT LAB,WIRRAL,MERSEYSIDE,ENGLAND
关键词
CLINICAL TRIAL; CARIES; SENSITIVITY; SUBJECT SELECTION;
D O I
10.1111/j.1600-0528.1991.tb00098.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
As caries prevalence in some countries declines, and panel sizes for discriminating anti-caries clinical trials inevitably increase, the need for participant pre-selection grows to avoid escalating cost and manpower problems. Hence, retrospective analyses of data were undertaken, from a 3-yr double-blind caries clinical trial where a linear fluoride dose-response had been obtained. As a result, it was demonstrated that the eruption status of permanent second molars, in 3005 participants aged 11-12 yr at outset, when coupled with their baseline clinical DMFT values, provided a sound basis for panellist size prediction without loss of sensitivity. Thus, had only those subjects with DMFT > 4, with at least three of their permanent second molars erupted been selected following clinical baseline examination, the same sensitivity would have been achieved with 52% fewer subjects. Furthermore, using these criteria, selection can be made on site, in real time, and a child informed whether its immediate participation in a trial is possible.
引用
收藏
页码:20 / 22
页数:3
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