GAS-PHASE CLEAVAGE OF PEPTIDES FROM A SOLID SUPPORT WITH AMMONIA VAPOR - APPLICATION IN SIMULTANEOUS MULTIPLE PEPTIDE-SYNTHESIS

被引：51

作者：

BRAY, AM ^{[1
]}

MAEJI, NJ ^{[1
]}

JHINGRAN, AG ^{[1
]}

VALERIO, RM ^{[1
]}

机构：

[1] COSELCO MIMOTOPES PTY LTD,POB 40,CLAYTON,VIC 3168,AUSTRALIA

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 43期

关键词：

D O I：

10.1016/0040-4039(91)80779-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Support-bound peptide esters are cleaved with ammonia vapour and then eluted from the support with a solvent of choice. The method is demonstrated in conjunction with the multipin method of peptide synthesis.

引用

页码：6163 / 6166

页数：4

共 16 条

[1] PEPTIDE-SYNTHESIS .2. PROCEDURES FOR SOLID-PHASE SYNTHESIS USING N-ALPHA-FLUORENYLMETHOXYCARBONYLAMINO-ACIDS ON POLYAMIDE SUPPORTS - SYNTHESIS OF SUBSTANCE-P AND OF ACYL CARRIER PROTEIN 65-74 DECAPEPTIDE
ATHERTON, E
LOGAN, CJ
SHEPPARD, RC
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1981, (02): : 538 - 546
[2] STRUCTURE OF PEPTIDE ANTIBIOTIC AMPHOMYCIN
BODANSZKY, M
SIGLER, GF
BODANSZKY, A
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (07) : 2352 - 2357
[3] THE SIMULTANEOUS MULTIPLE PRODUCTION OF SOLUTION PHASE PEPTIDES - ASSESSMENT OF THE GEYSEN METHOD OF SIMULTANEOUS PEPTIDE-SYNTHESIS
BRAY, AM
MAEJI, NJ
GEYSEN, HM
[J]. TETRAHEDRON LETTERS, 1990, 31 (40) : 5811 - 5814
[4] BRAY AM, 1991, IN PRESS J ORG CHEM
[5] PEPTIDE-SYNTHESIS .5. SOLID-PHASE SYNTHESIS OF [15-LEUCINE]LITTLE GASTRIN
BROWN, E
SHEPPARD, RC
WILLIAMS, BJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1983, (06): : 1161 - 1167
[6] SIMULTANEOUS MULTIPLE PEPTIDE-SYNTHESIS UNDER CONTINUOUS-FLOW CONDITIONS ON CELLULOSE PAPER DISKS AS SEGMENTAL SOLID SUPPORTS
FRANK, R
DORING, R
[J]. TETRAHEDRON, 1988, 44 (19) : 6031 - 6040
[7] STRATEGIES FOR EPITOPE ANALYSIS USING PEPTIDE-SYNTHESIS
GEYSEN, HM
RODDA, SJ
MASON, TJ
TRIBBICK, G
SCHOOFS, PG
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1987, 102 (02) : 259 - 274
[8] USE OF PEPTIDE-SYNTHESIS TO PROBE VIRAL-ANTIGENS FOR EPITOPES TO A RESOLUTION OF A SINGLE AMINO-ACID
GEYSEN, HM
MELOEN, RH
BARTELING, SJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (13): : 3998 - 4002
[9] GENERAL-METHOD FOR THE RAPID SOLID-PHASE SYNTHESIS OF LARGE NUMBERS OF PEPTIDES - SPECIFICITY OF ANTIGEN-ANTIBODY INTERACTION AT THE LEVEL OF INDIVIDUAL AMINO-ACIDS
HOUGHTEN, RA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (15) : 5131 - 5135
[10] METHODOLOGICAL IMPLICATIONS OF SIMULTANEOUS SOLID-PHASE PEPTIDE-SYNTHESIS .1. COMPARISON OF DIFFERENT COUPLING PROCEDURES
HUDSON, D
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (03) : 617 - 624

← 1 2 →