FED-BATCH CULTURE FOR L-LYSINE PRODUCTION VIA ONLINE STATE ESTIMATION AND CONTROL

被引：10

作者：

LIU, YC

WU, WT

TSAO, JH

机构：

[1] NATL TSING HUA UNIV,DEPT CHEM ENGN,HSINCHU 300,TAIWAN

[2] IND TECHNOL RES INST,UNION CHEM LABS,HSINCHU,TAIWAN

来源：

BIOPROCESS ENGINEERING | 1993年 / 9卷 / 04期

关键词：

D O I：

10.1007/BF00389920

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Computer application for fed-batch culture of Brevibacterium flavum for L-lysine production has been developed. The organisms are auxotrophic mutants for L-homoserine and are resistant to S-(2-aminoethyl)-L-cysteine. Adaptive control is applied for substrate addition. The sugar concentration is estimated using on-line respiratory measurement. During the period of fed-batch culture, the total sugar concentration is maintained at a given value. The cultivation strategy results in high productivity and high conversion yield.

引用

页码：135 / 139

页数：5

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