THE DEVELOPMENT OF A MICROWAVE FLUID-BED PROCESSOR .2. DRYING PERFORMANCE AND PHYSICAL CHARACTERISTICS OF TYPICAL PHARMACEUTICAL GRANULATIONS

被引：12

作者：

DOELLING, MK ^{[1
]}

NASH, RA ^{[1
]}

机构：

[1] ST JOHNS UNIV,COLL PHARM & ALLIED HLTH PROFESS,JAMAICA,NY 11439

来源：

PHARMACEUTICAL RESEARCH | 1992年 / 9卷 / 11期

关键词：

MICROWAVE DRYER; FLUID-BED DRYER; PROCESS EQUIPMENT VALIDATION;

D O I：

10.1023/A:1015827416892

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four typical pharmaceutical granulations were used to measure the enhanced drying performance of a laboratory-sized microwave fluid-bed processor, the design and construction of which were presented in Part I of this work (preceding paper). Results demonstrate improvements in observed drying rates by as much as sixfold depending upon the granulation type and drying conditions. At a low inlet temperature (30-degrees-C), drying was achieved with microwave power inputs of 100-125 W/liter of working capacity, whereas similar targeted moisture levels were unattainable using conventional fluid-bed drying. Microwave energy available for heating and drying was 68 to 86% of the total microwave energy inputted.

引用

页码：1493 / 1501

页数：9