SCHIZOPHRENIA AND GABA(A) RECEPTOR SUBUNIT GENES

被引：14

作者：

BYERLEY, W

BAILEY, MES

HICKS, AA

RILEY, BP

DARLISON, MG

HOLIK, J

HOFF, M

UMAR, F

REIMHERR, F

WENDER, P

MYLESWORSLEY, M

WALDO, M

FREEDMAN, R

JOHNSON, KJ

COON, H

机构：

[1] UNIV UTAH,SCH MED,DEPT PSYCHIAT,SALT LAKE CITY,UT 84132

[2] CHARING CROSS & WESTMINSTER MED SCH,DEPT ANAT,GENET UNIT,LONDON W6 8RP,ENGLAND

[3] CNRS,GENET MOLEC NEUROTRANSMISS & PROC NEURODEGENERATI,F-91198 GIF SUR YVETTE,FRANCE

[4] ST MARYS HOSP,IMPERIAL COLL,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON W2 1PG,ENGLAND

[5] UNIV HAMBURG,KRANKENHAUS EPPENDORF,INST ZELLBIOL,D-20246 HAMBURG,GERMANY

[6] UNIV HAMBURG,KRANKENHAUS EPPENDORF,NEUROBIOL KLIN,D-20246 HAMBURG,GERMANY

[7] UNIV COLORADO,HLTH SCI CTR,DEPT PSYCHIAT,DENVER,CO

来源：

PSYCHIATRIC GENETICS | 1995年 / 5卷 / 01期

基金：

英国惠康基金;

关键词：

SCHIZOPHRENIA; GABA(A); RECEPTOR SUBUNIT GENES; LINKAGE ANALYSIS;

D O I：

10.1097/00041444-199521000-00004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Alterations in gamma-aminobutyric acid (GABA) neurotransmission have been indirectly implicated in the pathogenesis of schizophrenia. Using nine multiplex pedigrees, we tested for linkage between schizophrenia and simple sequence repeat polymorphisms for the GABA(A) receptor alpha 1, alpha 2, alpha 4, alpha 5, alpha 6, beta 1 and beta 3 subunit genes. Evidence of linkage was not found when assuming either autosomal dominant or autosomal recessive inheritance. The non-parametric sib pair test also did not reveal significant evidence of deviation from expected segregation ratios.

引用

页码：23 / 29

页数：7

共 52 条

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