PREPARATION OF MAPPICINE KETONES FROM CAMPTOTHECINS - CHEMISTRY OF THE CAMPTOTHECIN E-RING

被引：22

作者：

FORTUNAK, JMD ^{[1
]}

MASTROCOLA, AR ^{[1
]}

MELLINGER, M ^{[1
]}

WOOD, JL ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT SYNTHET CHEM,KING OF PRUSSIA,PA 19406

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(00)78177-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Camptothecin and its analogs are thermolyzed at 150-200 degrees C to yield mappicine ketone derivatives by loss of carbon dioxide from the alpha-hydroxylactone.

引用

页码：5763 / 5764

页数：2

共 7 条

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[7] PLANT ANTITUMOR AGENTS .I. ISOLATION AND STRUCTURE OF CAMPTOTHECIN A NOVEL ALKALOIDAL LEUKEMIA AND TUMOR INHIBITOR FROM CAMPTOTHECA ACUMINATA [J].

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