PYRAZOLO [3,4-D]PYRIMIDINES - ADENOSINE RECEPTOR SELECTIVITY

被引：10

作者：

CHEBIB, M ^{[1
]}

QUINN, RJ ^{[1
]}

机构：

[1] GRIFFITH UNIV,QUEENSLAND PHARMACEUT RES INST,BRISBANE,QLD 4111,AUSTRALIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 20期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0960-894X(95)00420-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Substitution of 1-phenylpyrazolo[3,4-d]pyrimidines at C6 (corresponding to C2 of xanthines/ adenosines) with thioethers containing amide moieties has resulted in compounds with A(1) and A(2a) adenosine receptor selectivity. This further demonstrates that distal moieties can modify receptor selectivity.

引用

页码：2409 / 2412

页数：4

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