ASSOCIATION OF SPERM RECEPTOR ACTIVITY WITH A PURIFIED PIG ZONA ANTIGEN (PPZA)

被引：65

作者：

SACCO, AG

SUBRAMANIAN, MG

YUREWICZ, EC

机构：

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1984年 / 6卷 / 02期

关键词：

D O I：

10.1016/0165-0378(84)90003-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three types of data are presented which suggest that sperm receptor activity is associated with a 58,000 MW acidic glycoprotein (PPZA) isolated from pig zonae. Boar sperm failed to bind to pig zonae pretreated with univalent antibody to PPZA. Boar sperm pretreated with PPZA were inhibited in binding to intact pig zonae binding studies utilizing boar sperm, and radiolabeled PPZA indicate an inhibition of radiolabeled PPZA binding to sperm by non-labeled PPZA in a dose-related manner. At least in the pig system, the contraceptive action of zona antibodies is accomplished by a specific immunologic reaction between antibody and the zona sperm receptor site rather than to a nonspecific blockage of this receptor.

引用

页码：89 / 103

页数：15

共 29 条

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