PHOSPHOLIPIDS CHIRAL AT PHOSPHORUS .19. PHOSPHOLIPIDS CHIRAL AT PHOSPHORUS - SYNTHESIS AND CONFIGURATIONAL ASSIGNMENT OF PHOSPHOROTHIOATE ANALOGS OF PHOSPHATIDYLSERINE

被引：15

作者：

LOFFREDO, WM ^{[1
]}

TSAI, MD ^{[1
]}

机构：

[1] OHIO STATE UNIV,DEPT CHEM,COLUMBUS,OH 43210

来源：

BIOORGANIC CHEMISTRY | 1990年 / 18卷 / 01期

关键词：

D O I：

10.1016/0045-2068(90)90017-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorothioate analogs of phosphatidylserine, (Rp + Sp)-1,2-dipalmitoyl-sn-glycero-3-thiophospho-l-serine were synthesized from 1,2-dipalmitoyl-sn-glycerol and N-trityl-l-serine methoxymethyl ester, using chloro(N,N-diisopropylamino)methoxyphosphine as a phosphitylating agent. The configuration at phosphorus of these phosphorothioate analogs was assigned on the basis of the stereospecific hydrolysis of the Rp isomer by phospholipase A2 from bee venom. © 1990.

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页码：78 / 84

页数：7

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