REDUCTION IN CD4 BINDING-AFFINITY ASSOCIATED WITH REMOVAL OF A SINGLE GLYCOSYLATION SITE IN THE EXTERNAL GLYCOPROTEIN OF HIV-2

被引：34

作者：

MORIKAWA, Y

MOORE, JP

WILKINSON, AJ

JONES, IM

机构：

[1] NERC,INST VIROL,MANSFIELD RD,OXFORD OX1 3SR,ENGLAND

[2] INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND

[3] UNIV YORK,DEPT CHEM,YORK YO1 5DD,N YORKSHIRE,ENGLAND

来源：

VIROLOGY | 1991年 / 180卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0042-6822(91)90106-L

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The role of selected glycosylation sites in the ability of the envelope glycoprotein of HIV-2 (gp105) to bind to CD4 has been investigated. Loss of glycosylation sites at amino acids 410 and 447 did not affect the CD4 binding ability of gp105 even when removed in pair combination. Loss of a single glycosylation site at amino acid 400, however, was sufficient to cause a reduction of at least 50-fold in the efficiency of receptor binding. These data support the hypothesis that some of the carbohydrate side chains on gp106 have a profound effect on biological activity. © 1991.

引用

收藏

页码：853 / 856

页数：4

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