ISOLATION AND STRUCTURE OF THE SYMMETRICAL DISTEROIDAL ALKALOIDS CEPHALOSTATIN-12 AND CEPHALOSTATIN-13

被引：27

作者：

PETTIT, GR ^{[1
]}

ICHIHARA, Y ^{[1
]}

XU, JP ^{[1
]}

BOYD, MR ^{[1
]}

WILLIAMS, MD ^{[1
]}

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80522-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Re-examination of a Western Indian Ocean worm Cephalodiscus gilchristi has led to discovery of cephalostatins 12 and 13. Cephalostatin 12 (2) proved to be the first example of a symmetrical disteroidal alkaloid. Both new cephalostatins significantly inhibited growth of animal and human cancer cell lines.

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页码：1507 / 1512

页数：6

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