PROVOCATION OF VENTRICULAR-TACHYCARDIA BY ANTIMALARIAL DRUG HALOFANTRINE IN CONGENITAL LONG QT SYNDROME

被引：27

作者：

TOIVONEN, L ^{[1
]}

VIITASALO, M ^{[1
]}

SIIKAMAKI, H ^{[1
]}

RAATIKKA, M ^{[1
]}

POHJOLASINTONEN, S ^{[1
]}

机构：

[1] AURORA HOSP,SF-00250 HELSINKI,FINLAND

来源：

CLINICAL CARDIOLOGY | 1994年 / 17卷 / 07期

关键词：

HALOFANTRINE; QT INTERVAL; VENTRICULAR ARRHYTHMIA;

D O I：

10.1002/clc.4960170711

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This report deals with two patients who suffered sustained episodes of torsade de pointes ventricular tachycardia while using the novel antimalarial drug halofantrine. Both patients had congenital long QT syndrome, and their QT interval was further prolonged at the time of the event. This first electrocardiographic documentation of ventricular arrhythmias together with halofantrine's known prolonging effect on the QT interval demonstrates that the drug has the potential to induce life-threatening arrhythmias.

引用

页码：403 / 404

页数：2

共 7 条

[1] TORSADES-DE-POINTES VENTRICULAR-TACHYCARDIA AND TERODILINE [J].