IMPACT OF FONTAN OPERATION ON LEFT-VENTRICULAR SIZE AND CONTRACTILITY IN TRICUSPID ATRESIA

被引:70
作者
GEWILLIG, MH
LUNDSTROM, UR
DEANFIELD, JE
BULL, C
FRANKLIN, RC
GRAHAM, TP
WYSE, RK
机构
[1] HOSP SICK CHILDREN, DEPT PAEDIAT CARDIOL, CARDIOTHORAC UNIT, GREAT ORMOND ST, LONDON WC1 3JH, ENGLAND
[2] VANDERBILT MED CTR N, DIV PAEDIAT CARDIOL, NASHVILLE, TN USA
关键词
Contractility; Fontan procedure; Volume loading;
D O I
10.1161/01.CIR.81.1.118
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Left ventricular dimensions and contractility were determined by echocardiography in 33 patients with tricuspid atresia in 1985 and again in 1988. Eight patients remained palliated throughout the 3-year period; neither the left ventricular end-diastolic diameter (153±15% of normal vs. 157±19%, p=NS) nor a load-independent index of contractility (rate-corrected velocity of shortening [VCFc]/end-systolic meridional stress [ESSM]) changed. Eleven patients underwent a Fontan operation during the study and were reevaluated at least 6 months after surgery; left ventricular dimension decreased (130±15% vs. 114±19%, p<0.001), and the contractility index VCFc/ESSM improved (p<0.05). Fourteen patients had undergone a Fontan operation 0.9-9.5 years (mean, 4.2 years) before initial examination in 1985. Over the 3-year period, left ventricular dimensions did not change (121±17% vs. 118±11%, p=NS), but the contractility index showed significant improvement (p<0.01). Eight additional patients were studied just before and after a Fontan operation to examine the early effects of surgery. Left ventricular dimensions decreased from 130±14% to 100±13% by 10 days p<0.001) with no further change at 2 months. An inappropriate degree of ventricular hypertrophy was observed in only the early postoperative period. Successful Fontan repair results in rapid reduction of left ventricular size, followed by regression of hypertrophy to a normal mass-to-volume ratio. Operating at more favorable dimensions and loading conditions results in an early increase in left ventricular contractility, which further improves in the medium term follow-up.
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页码:118 / 127
页数:10
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