INDIRECT DETERMINATION OF ALKALOIDS AND DRUGS BY ATOMIC-ABSORPTION SPECTROMETRY

被引：30

作者：

NERIN, C ^{[1
]}

GARNICA, A ^{[1
]}

CACHO, J ^{[1
]}

机构：

[1] UNIV SARAGOSSA,FAC CIENCIAS,DEPT QUIM ANALIT,SARAGOSSA,SPAIN

来源：

ANALYTICAL CHEMISTRY | 1985年 / 57卷 / 01期

关键词：

ALKALOIDS - INDIRECT DETERMINATION - ORGANIC PHASE - PAPAVERINE - PROCAINE;

D O I：

10.1021/ac00279a013

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new procedure for determination of alkaloids and other pharmaceutical drugs is described. The method consists of extracting an ion pair between the organic base and the inorganic complex Co(SCN)//4**2** minus and measuring Co in the organic phase by AAS at 241. 0 nm. The optimal experimental conditions pH, concentration of Co(SCN)//4**2** minus , shaking time, phase ratio, number of extractions, and the lineal range of calibration are studied in the determination of amylocaine, papaverine, sparteine, procaine, quinine, codeine, atropine, pilocarpine, and avacan. The organic phase used is 1,2-dichloroethane. The standard deviation of the method varies between 10** minus **1 and 10** minus **2, depending on the substance analyzed. The new method allows the determination of amylocaine in the presence of procaine, avacan in the presence of pilocarpine, procaine, or quinine, and papaverine in the presence of pilocarpine or sparteine.

引用

页码：34 / 38

页数：5

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