STUDIES ON THE SYNTHESIS OF SESQUITERPENE LACTONES .12. SYNTHESIS OF (+)-COLARTIN, (+)-ARBUSCULIN-A, AND THEIR C-4 EPIMERS AND THEIR BIOLOGICAL-ACTIVITIES

被引：40

作者：

ANDO, M

ISOGAI, K

AZAMI, H

HIRATA, N

YANAGI, Y

机构：

[1] TOHOKU UNIV,FAC SCI,DEPT CHEM,SENDAI,MIYAGI 980,JAPAN

[2] SUMITOMO CHEM CO LTD,PESTICIDES RES LAB,TAKARAZUKA,HYOGO 665,JAPAN

[3] SUMITOMO CHEM CO LTD,RES LABS,TAKARAZUKA,HYOGO 665,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 04期

关键词：

D O I：

10.1021/np50076a015

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Colartin [9] and arbusculin A [11] have been synthesized from alpha-santonin [1] in 14.5% (11 steps) and 9.3% (13 steps) overall yields, respectively. Arbusculin A [11] and compounds 20, 21, and 22, which were derived from intermediate 2, showed significant cell growth inhibitory activity against murine lymphocytic leukemia (P-388) in vitro. Plant growth regulating activity of 11 and its synthetic intermediates 4, 5, 8, and 9 was also studied.

引用

页码：1017 / 1024

页数：8

共 13 条

[1] STUDIES ON THE SYNTHESES OF SESQUITERPENE LACTONES .11. THE SYNTHESES OF 3-EPIZALUZANIN-C, ZALUZANIN-C, ZALUZANIN-D, AND RELATED-COMPOUNDS 3ALPHA-HYDROXYGUAIA-1(10),4(15),11(13)-TRIENO-12,6ALPHA-LACTONE AND 3ALPHA-HYDROXYGUAIA-4(15),9,11(13)-TRIENO-12,6ALPHA-LACTONE [J].