MUCOSAL DE-NOVO CANCER OF THE RECTUM FOLLOWING RADIATION-THERAPY FOR UTERINE-CANCER

被引:1
作者
MATSUO, T
ITO, M
SEKINE, I
KISHIKAWA, M
TAKETOMI, K
机构
[1] The Department of Pathology, Atomic Disease Institute, Nagasaki
[2] The Department of Pathology, Scientific Data Center of Atomic Bomb Disaster, Nagasaki University School of Medicine, Nagasaki
[3] The Department of Surgery, Isahaya Insurance General Hospital, Isahaya
关键词
RECTAL CANCER; UTERINE CANCER;
D O I
10.2169/internalmedicine.32.427
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 54-year-old woman who underwent a hysterectomy and radiation therapy for carcinoma of the uterine cervix developed mucosal de novo cancer of the rectum 12 years later. The rectal lesion was elevated, measuring 0.8x0.7x0.3cm, and its surface was relatively smooth. Microscopically, this tumor consisted of a well-differentiated tubular adenocarcinoma which had invaded the depth of the mucosa. Late radiation injuries were observed around the tumor. We diagnosed this lesion as a radiation-induced mucosal de novo adenocarcinoma of the rectum on the basis of the criteria of Black and Ackerman (Clin Radiol 16: 278,1965). This case underscores the need for careful long-term follow-up studies of the large intestines of patients who underwent therapeutic irradiation for uterine cancer.
引用
收藏
页码:427 / 429
页数:3
相关论文
共 14 条
[1]  
Slaughter D.P., Southwick H.W., Mucosal carcinoma as a result of irradiation, Arch Surg, 74, (1957)
[2]  
Black W.C., Ackermann L.V., Carcinoma of the large intestine as a late complication of pelvic radiotherapy, Clin Radiol, 16, (1965)
[3]  
Boice J.D., Cancer following medical irradiation, Cancer, 47, (1981)
[4]  
Pizzarello D., Roses D.F., Newall J., Et al., The carcinogenicity of radiation therapy, Surg Gynecol Obst, 159, (1984)
[5]  
Castro E.L.B., Rosen P.P., Quan S.H., Et al., Carcinoma of large intestine in patients irradiated for carcinoma of cervix uterus, Cancer, 31, (1973)
[6]  
Takeichi N., Hirose F., Yamamoto H., Et al., Salivary gland tumors in atomic bomb survivors, Hiroshima, Japan, Cancer, 38, 1, (1976)
[7]  
Upton A.C., The question of thresholds for radiation and chemical carcinogenesis, Cancer Invest, 7, (1989)
[8]  
Harris H., The analysis of malignancy by cell fusion
[9]  
the position in 1988, Cancer Res, 48, (1988)
[10]  
Klein G., The approaching era of the tumor suppressor genes, Science, 238, (1987)