Ethanol-induced single-strand DNA breaks in rat brain cells

被引：52

作者：

Singh, NP ^{[1
]}

Lai, H ^{[1
]}

Khan, A ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH MED,DEPT PHARMACOL,SEATTLE,WA 98195

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY | 1995年 / 345卷 / 3-4期

关键词：

ethanol; brain cell; alkaline microgel electrophoresis; single-strand DNA break; DNA damage repair;

D O I：

10.1016/0165-1218(95)90054-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Male Sprague-Dawley rats were intubated with 4 g/kg body weight of ethanol (in a 20%, v/v, water solution). Brain cells were analyzed for single-strand DNA breaks at various post-ethanol administration time points using an alkaline microgel electrophoresis assay. Results showed a significant increase in single-strand DNA breaks in brain cells that peaked at approx. 4 h and returned to control level within 6 h after ethanol administration.

引用

页码：191 / 196

页数：6

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