A RANDOMIZED, CROSSOVER EVALUATION OF METHYLPHENIDATE IN CANCER-PATIENTS RECEIVING STRONG NARCOTICS

被引:76
作者
WILWERDING, MB
LOPRINZI, CL
MAILLIARD, JA
OFALLON, JR
MISER, AW
VANHAELST, C
BARTON, DL
FOLEY, JF
ATHMANN, LM
机构
[1] MAYO CLIN & MAYO FDN, DIV MED ONCOL, ROCHESTER, MN 55905 USA
[2] CREIGHTON UNIV, UNIV NEBRASKA MED CTR & ASSOCIATES, NEBRASKA ONCOL GRP, OMAHA, NE 68131 USA
[3] MAYO CLIN & MAYO FDN, CTR CANC, STAT UNIT, ROCHESTER, MN 55905 USA
[4] CARLE CANC CTR, COMMUNITY CLIN ONCOL PROGRAM, URBANA, IL 61801 USA
[5] DULUTH COMMUNITY CLIN ONCOL PROGRAM, DULUTH, MN 55805 USA
关键词
METHYLPHENIDATE; NARCOTIC-INDUCED SEDATION; PSYCHOSTIMULANTS;
D O I
10.1007/BF00365854
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Sedation may be a dose limiting side-effect of opioid therapy in some cancer patients. This study was designed to evaluate further the use of the psychostimulant, methylphenidate, an agent that has been reported to counteract opioid-induced sedation, in patients with cancer-related pain. Patients receiving a stable dose of an opioid for cancer-related pain were recruited for this randomized, double-blind, crossover clinical trial. In addition to their regular dose of narcotics, they received 5 days of methylphenidate followed by 5 days of placebo, or vice versa. Our data did not definitively demonstrate any statistically significant benefit for methylphenidate, but did suggest that this drug could mildly decrease narcotic-induced drowsiness and could increase night-time sleep. These data, in conjunction with other published data, suggest that methylphenidate can counteract narcotic-induced daytime sedation to a limited degree.
引用
收藏
页码:135 / 138
页数:4
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