TRANSMEMBRANE SIGNALING VIA HLA-DR MOLECULES ON T-CELLS FROM A SEZARY T-CELL LEUKEMIA LINE

被引：14

作者：

GEISLER, C ^{[1
]}

KUHLMANN, J ^{[1
]}

MOLLER, T ^{[1
]}

PLESNER, T ^{[1
]}

RUBIN, B ^{[1
]}

机构：

[1] UNIV COPENHAGEN,INST EXPTL IMMUNOL,DK-1168 COPENHAGEN,DENMARK

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1990年 / 32卷 / 06期

关键词：

D O I：

10.1111/j.1365-3083.1990.tb03217.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human Sezary T‐cell leukaemia line. HUT.78, represents a population of activated T cells, i.e. they are HLA‐DR+ and IL‐2R+. We have analysed the capacity of HUT.78cells (1) to stimulate HLA‐DR‐specific T‐cell lines or clones and (2) to be induced to synthesize IL‐2 by anti‐HLA‐DR monoclonal antibodies. The results of our experiments show that HLA‐DR molecules on HUT.78 cells can stimulate at least one HLA‐DR‐specific T‐cell clone and can act as transmembrane signal transmitters. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：731 / 735

页数：5

共 26 条

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[2]

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