EFFECT OF SURGERY ON THE SYSTEMIC INFLAMMATORY RESPONSE TO INTERMITTENT CLAUDICATION

被引：42

作者：

HICKEY, NC ^{[1
]}

GOSLING, P ^{[1
]}

BAAR, S ^{[1
]}

SHEARMAN, CP ^{[1
]}

SIMMS, MH ^{[1
]}

机构：

[1] SELLY OAK HOSP,DEPT BIOCHEM,BIRMINGHAM B29 6JD,ENGLAND

来源：

BRITISH JOURNAL OF SURGERY | 1990年 / 77卷 / 10期

关键词：

albuminuria; Ischaemia; neutrophils;

D O I：

10.1002/bjs.1800771015

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The hypothesis that intermittent claudication initiates a systemic inflammatory response was investigated by studying the effect of exercise on markers of neutrophil activation and vascular permeability in 25 claudicants and 10 controls. Urinary albumin excretion, previously demonstrated to reflect vascular permeability, increased significantly after exercise in claudicants and was associated with decreased neutrophil fllterability and increased serum lysozyme activity. No similar exercise‐induced changes were seen in controls or in claudicants after successful arterial bypass surgery. These results suggest that intermittent claudication is associated with potentially deleterious systemic manifestations that are surgically reversible. Copyright © 1990 British Journal of Surgery Society Ltd.

引用

页码：1121 / 1124

页数：4

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