PREPARATION OF FUNCTIONALIZED ZINC AND COPPER ORGANOMETALLICS CONTAINING SULFUR FUNCTIONALITIES AT THE ALPHA-POSITION OR GAMMA-POSITION

被引：7

作者：

ACHYUTHARAO, S ^{[1
]}

TUCKER, CE ^{[1
]}

KNOCHEL, P ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT CHEM,WILLARD H DOW LABS,ANN ARBOR,MI 48109

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(00)97302-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Chloroalkyl phenyl sulfides 1 readily insert zinc in THF at 25-degrees-C (0.5-2 h), affording sulfur stabilized organozinc derivatives of type 2. The presence of a functional group such as an ester or a cyano group is tolerated in these organometallics. After a transmetallation to the corresponding copper reagent 3, they react with a wide range of electrophiles. Zinc and copper organometallics bearing a thiophenyl or a phenylsulfinyl group at the gamma-position have also been prepared showing the generality of our approach.

引用

页码：7575 / 7578

页数：4

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