DECREASED HEAT-MEDIATED AND TUMOR NECROSIS FACTOR-MEDIATED HSP28 PHOSPHORYLATION IN THERMOTOLERANT HELA-CELLS

被引：25

作者：

ARRIGO, AP ^{[1
]}

MICHEL, MR ^{[1
]}

机构：

[1] UNIV BERN,SCH MED,INST MED MICROBIOL,CH-3010 BERN,SWITZERLAND

来源：

FEBS LETTERS | 1991年 / 282卷 / 01期

关键词：

THERMOTOLERANCE; HEAT SHOCK PROTEIN PHOSPHORYLATION; TUMOR NECROSIS FACTOR;

D O I：

10.1016/0014-5793(91)80466-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heat shock or tumor necrosis factor rapidly stimulated the phosphorylation of the mammalian low molecular weight stress protein hsp28. We have found that both phenomena are greatly decreased in cells which are made tolerant to heat. This observation correlated with a better survival of thermotolerant cells exposed to either heat or TNF treatment. The results suggest that the phosphorylation of hsp28 may be linked to the resistance of the cells to the deleterious effects induced by either heat or a mediator of inflammation such as TNF.

引用

页码：152 / 156

页数：5

共 31 条

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