NOVEL CELL-JUNCTIONS INDUCED BY ACTIVATING THY-1-SPECIFIC ANTIBODIES

被引：8

作者：

MILLRAIN, MM ^{[1
]}

HEDERER, R ^{[1
]}

GRIFFITHS, S ^{[1
]}

FRYER, P ^{[1
]}

TOMONARI, K ^{[1
]}

ROBINSON, PJ ^{[1
]}

机构：

[1] CLIN RES CTR,WATFORD RD,HARROW HA1 3UJ,MIDDX,ENGLAND

来源：

INTERNATIONAL IMMUNOLOGY | 1992年 / 4卷 / 10期

关键词：

CELL ADHESION; GPI-ANCHORED MEMBRANE PROTEINS; T-CELL ACTIVATION; THY-1;

D O I：

10.1093/intimm/4.10.1137

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

KT16, like other anti-Thy-1 antibodies, induces T cell aggregation. Protein A - gold labelling shows the antibody to be concentrated along areas of intercellular contacts. Electron micrographs of KT16 treated T cells reveal a consistent type of junction between the cells. We demonstrate that this type of cell junction is Thy-1 specific, is predominantly the property of antibodies directed against a particular epitope, and is distinct from cellular aggregation caused by concanavalin A or anti-CD3 antibodies. The degree of adhesiveness induced by different anti-Thy-1 antibodies is related to their mitogenic capacity.

引用

收藏

页码：1137 / 1143

页数：7

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