FLOW CYTOMETRIC DNA ANALYSIS OF SQUAMOUS-CELL CARCINOMAS OF THE ORAL CAVITY - CORRELATION WITH CLINICAL AND HISTOPATHOLOGICAL FEATURES

被引:14
作者
BALSARA, BR
BORGES, AM
PRADHAN, SA
RAJPAL, RM
BHISEY, AN
机构
[1] TATA MEM HOSP,TATA MEM CTR,CANC RES INST,BOMBAY 400012,MAHARASHTRA,INDIA
[2] TATA MEM HOSP,TATA MEM CTR,DEPT PATHOL,BOMBAY 400012,INDIA
[3] TATA MEM HOSP,TATA MEM CTR,DEPT SURG,BOMBAY 400012,INDIA
来源
ORAL ONCOLOGY-EUROPEAN JOURNAL OF CANCER PART B | 1994年 / 30B卷 / 02期
关键词
D O I
10.1016/0964-1955(94)90060-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
DNA content was measured in 68 squamous cell carcinomas (SCC) of the oral cavity by flow cytometry. Samples fixed in 95% alcohol and disaggregated with 0.5% pepsin were stained with 4,6-diamidino-phenylindole (DAPI) for flow cytometry. The tumours were classified according to the TNM classification-1987, and graded histopathologically. A positive correlation between tumour size and ploidy status was observed. Poorly differentiated tumours were mainly non-diploid (P<0.01, (chi)2) A majority of the node positive (N+) tumours were non-diploid (P<0.05). It was possible to distinguish diploid, N+,T4 tumours from diploid, N-, T4 tumours by their higher S-phase fraction (SpF). SpF was also a useful parameter to differentiate diploid, N+ tumours from diploid, N-tumours among the moderately differentiated (MD) SCC. These results suggest that ploidy and SpF can be useful correlates of tumour behaviour.
引用
收藏
页码:98 / 101
页数:4
相关论文
共 19 条
[1]   PROGNOSTIC SIGNIFICANCE OF HISTOLOGIC GRADE IN EPIDERMOID CARCINOMA OF MOUTH AND PHARYNX [J].
ARTHUR, K ;
FARR, HW .
AMERICAN JOURNAL OF SURGERY, 1972, 124 (04) :489-&
[2]   SURGICAL PATHOLOGY OF SQUAMOUS CARCINOMA OF THE ORAL CAVITY - ITS IMPACT ON MANAGEMENT [J].
BORGES, AM ;
SHRIKHANDE, SS ;
GANESH, B .
SEMINARS IN SURGICAL ONCOLOGY, 1989, 5 (05) :310-317
[3]  
BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
[4]  
DEAN PN, 1985, FLOW CYTOMETRY INSTR, P195
[5]   S-PHASE FRACTIONS AND DNA-PLOIDY OF OROPHARYNGEAL SQUAMOUS EPITHELIUM CARCINOMAS COMPARED WITH HISTOLOGIC GRADE, STAGE, RESPONSE TO CHEMOTHERAPY AND SURVIVAL [J].
FEICHTER, GE ;
MAIER, H ;
ADLER, D ;
BORN, IA ;
ABEL, U ;
HAAG, D ;
GOERTTLER, K .
ACTA OTO-LARYNGOLOGICA, 1987, 104 (3-4) :377-384
[6]   CLINICAL AND BIOLOGICAL SIGNIFICANCE OF ANEUPLOIDY IN HUMAN-TUMORS [J].
FRIEDLANDER, ML ;
HEDLEY, DW ;
TAYLOR, IW .
JOURNAL OF CLINICAL PATHOLOGY, 1984, 37 (09) :961-974
[7]  
GOHDE W, 1978, PULSE CYTOPHOTOMET 3, P229
[8]   INVITRO BROMODEOXYURIDINE LABELING OF SQUAMOUS-CELL CARCINOMAS OF THE ORAL CAVITY [J].
HEMMER, J .
EUROPEAN JOURNAL OF CANCER, 1990, 26 (02) :113-115
[9]   PROGNOSTIC IMPLICATIONS OF DNA PLOIDY IN SQUAMOUS-CELL CARCINOMAS OF THE TONGUE ASSESSED BY FLOW-CYTOMETRY [J].
HEMMER, J ;
SCHON, E ;
KREIDLER, J ;
HAASE, S .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1990, 116 (01) :83-86
[10]  
Hermanek P, 1987, TNM CLASSIFICATION M, V4, DOI [10.1007/978-3-642-82982-6, DOI 10.1007/978-3-642-82982-6]