INNERVATION OF PERIOSTEUM AND BONE BY SYMPATHETIC VASOACTIVE-INTESTINAL-PEPTIDE CONTAINING NERVE-FIBERS

被引：256

作者：

HOHMANN, EL

ELDE, RP

RYSAVY, JA

EINZIG, S

GEBHARD, RL

机构：

[1] UNIV MINNESOTA, SCH MED, DEPT ANAT, MINNEAPOLIS, MN 55455 USA

[2] UNIV MINNESOTA, SCH MED, DEPT RADIOL, MINNEAPOLIS, MN 55455 USA

[3] UNIV MINNESOTA, SCH MED, DEPT PEDIAT ONCOL, MINNEAPOLIS, MN 55455 USA

[4] VET ADM MED CTR, MINNEAPOLIS, MN 55455 USA

来源：

SCIENCE | 1986年 / 232卷 / 4752期

关键词：

D O I：

10.1126/science.3518059

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Neural control of bone metabolism and growth has been suggested, although the identity of participating neurons and neurotransmitters effecting this control has not been established. Immunohistochemical studies demonstrated a system of vasoactive intestinal peptide (VIP)-immunoreactive nerve fibers that innervate periosteum and bone in several mammalian species. Thoracic sympathetic chain ganglionectomy resulted in an ipsilateral loss of VIP-immunoreactive fibers in the periosteum of ribs, whereas dorsal root ganglionectomy has no effect. Injection of fast blue into rib periosteum labeled a population of VIP-immunoreactive sympathetic postganglionic neurons. Thus, postganglionic sympathetic neurons may provide an important means by which VIP regulates bone mineralization.

引用

页码：868 / 871

页数：4

共 20 条

[1]

CHANGES IN BLOOD-FLOW TO BONES DURING HYPOCALCEMIC AND HYPERCALCEMIC PHASES OF RESPONSE TO PARATHYROID-HORMONE [J].