PROSTAGLANDIN PRODUCTION IN RESPONSE TO ANGIOTENSIN-(1-7) IN RABBIT ISOLATED VASA DEFERENTIA

被引：52

作者：

TRACHTE, GJ ^{[1
]}

MEIXNER, K ^{[1
]}

FERRARIO, CM ^{[1
]}

KHOSLA, MC ^{[1
]}

机构：

[1] CLEVELAND CLIN EDUC FDN,RES INST,DEPT BRAIN & VASC RES,CLEVELAND,OH 44106

来源：

PROSTAGLANDINS | 1990年 / 39卷 / 04期

关键词：

D O I：

10.1016/0090-6980(90)90120-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiotensin-(1-7) is a predominant metabolite of angiotensin I in brain tissue. Its neuromodulatory and prostaglandin (PG) synthesizing capabilities were investigated in the rabbit isolated vas deferens. This metabolite had no significant effect as a neuromodulator, however it increased PGE synthesis in the vasa deferentia with a potency equivalent to that of angiotensin II. The angiotensin-(1-7) has a unique spectrum of activity among the angiotensin peptides to selectively increase PG synthesis. It could be useful in defining the relevance of angiotensin-induced PG synthesis in various systems, particularly in neuronal tissue. Angiotensin-(1-7) potentially could be useful in defining angiotensin receptor subtypes, as well. © 1990.

引用

页码：385 / 394

页数：10

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