SIGNAL TRANSDUCTION IN HUMAN MONOCYTES AND GRANULOCYTES THROUGH THE PI-LINKED ANTIGEN CD14

被引：44

作者：

LUNDJOHANSEN, F

OLWEUS, J

AARLI, A

BJERKNES, R

机构：

[1] UNIV BERGEN,HAUKELAND HOSP,BROEGELMANN RES LAB MICROBIOL,N-5021 BERGEN,NORWAY

[2] UNIV BERGEN,HAUKELAND HOSP,DEPT PEDIAT,N-5021 BERGEN,NORWAY

来源：

FEBS LETTERS | 1990年 / 273卷 / 1-2期

关键词：

Calcium; CD; 14; Flow cytometry; Leukocyte; Oxidative metabolism; Signal transduction;

D O I：

10.1016/0014-5793(90)81049-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A possible role for the Pi-linked CD14 molecule in human monocyte and granulocyte signal mediation was investigated. Using flow cytometry and the fluorescent indicators Fluo-3 and dihydrorhodamine-123 it was shown that crosslinking of the CD14 molecule induces an increase in monocyte and granulocyte cytoplasmic calcium concentration and monocyte H2O2 production. These responses were found to be independent of IgG Fc receptors and suggest an intrinsic signal mediating capacity of the CD 14 molecule. © 1990.

引用

页码：55 / 58

页数：4

共 19 条

[1] BIOCHEMICAL-CHARACTERIZATION OF A SOLUBLE FORM OF THE 53-KDA MONOCYTE SURFACE-ANTIGEN [J].