BETA-1-INTEGRIN-MEDIATED LYMPHOCYTE ADHERENCE TO EXTRACELLULAR-MATRIX IS ENHANCED BY PHORBOL ESTER TREATMENT

被引：120

作者：

WILKINS, JA

STUPACK, D

STEWART, S

CAIXIA, S

机构：

[1] CANADIAN RED CROSS, BLOOD TRANSFUS SERV, WINNIPEG, MANITOBA, CANADA

[2] SHANGHAI MED UNIV 2, DEPT IMMUNOL, SHANGHAI, PEOPLES R CHINA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 02期

关键词：

D O I：

10.1002/eji.1830210239

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interaction of the human T cell leukemia, Jurkat, with the extracellular matrix components collagen and fibronectin was examined. These cells displayed constitutive binding to fibronectin and low levels of adherence to collagen which were enhanced following stimulation with phorbol esters. The relevant binding structures were identified as members of the CD29/beta-1 integrin family of adhesion molecules. Adherence to collagen and to fibronectin was mediated by alpha-2-beta-1 and alpha-5-beta-1, respectively. The enhancement of adherence by phorbol esters did not involve up-regulation of receptor expression but appeared to derive from the increased functionality of structures which were expressed on the cell surface.

引用

收藏

页码：517 / 522

页数：6

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