DO G-PROTEIN SUBUNITS ASSOCIATE VIA A 3-STRANDED COILED COIL

被引：55

作者：

LUPAS, AN ^{[1
]}

LUPAS, JM ^{[1
]}

STOCK, JB ^{[1
]}

机构：

[1] PRINCETON UNIV,DEPT MOLEC BIOL,PRINCETON,NJ 08544

来源：

FEBS LETTERS | 1992年 / 314卷 / 02期

关键词：

G-PROTEIN TRIMERIZATION; G-PROTEIN STRUCTURE; TRANSDUCIN BETA-GAMMA-DIMER;

D O I：

10.1016/0014-5793(92)80952-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We used a computer-based prediction algorithm to identify probable coiled-coil segments at the N-termini of G protein alpha, beta and gamma subunits. This result indicates that G protein trimers may form via a three-stranded coiled coil. Previous biochemical results had shown that the N-termini of alpha and beta are involved in subunit interactions. Here we present a structural model for the N-terminal domain of betagamma and a hypothesis for the reversible association of alpha to betagamma.

引用

页码：105 / 108

页数：4

共 26 条

[1]

BLUMER KJ, 1991, ANNU REV PHYSIOL, V53, P37

[2]

BUBIS J, 1990, J BIOL CHEM, V265, P12995

[3] PHEROMONE-INDUCED PHOSPHORYLATION OF A G-PROTEIN BETA-SUBUNIT IN SACCHAROMYCES-CEREVISIAE IS ASSOCIATED WITH AN ADAPTIVE RESPONSE TO MATING PHEROMONE [J].