THE INHIBITORY EFFECT OF SESQUITERPENOID UNSATURATED DIALDEHYDES ON THE DOPAMINE D1 RECEPTOR, A QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS STUDY

被引：10

作者：

BOCCHIO, F

KALFHANSEN, S

DEKERMENDJIAN, K

STERNER, O

WITT, R

机构：

[1] UNIV LUND,CTR CHEM,DEPT ORGAN CHEM 2,POB 124,S-22100 LUND,SWEDEN

[2] SCT HANS MENTAL HOSP,DEPT BIOCHEM,DK-4000 ROSKILDE,DENMARK

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(00)61797-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The ability of 8 sesquiterpenoid unsaturated dialdehydes to inhibit the binding of the ligand H-3 SCH 23390 to the dopamine D1 receptor has been correlated with chemical and molecular features of the compounds by the multivariate PLS method. A good correlation was obtained, and the most important descriptors were found to be the dipole moment, the atomic charge on the alpha-carbon in the unsaturated aldehyde, and geometrical properties of the unsaturated dialdehyde functionality.

引用

页码：6867 / 6870

页数：4

共 9 条

[1]

ANKE H, 1991, PLANTA MED, V575, P344

[2]

CAMAZINE S, 1983, J CHEM ECOL, V10, P1439

[3] INSECT ANTIFEEDANT ACTIVITY AND HOT TASTE FOR HUMANS OF SELECTED NATURAL AND SYNTHETIC 1,4-DIALDEHYDES [J].