GAMETIC IMPRINTING AS A SPECIATION MECHANISM IN MAMMALS

被引：17

作者：

VARMUZA, S

机构：

[1] Department of Zoology, University of Toronto, Toronto, ON

来源：

JOURNAL OF THEORETICAL BIOLOGY | 1993年 / 164卷 / 01期

关键词：

D O I：

10.1006/jtbi.1993.1137

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gametic imprinting renders mammalian male and female genomes functionally hemizygous at specific loci. Successful embryogenesis can only be accomplished in the presence of both parental genomes. The mechanism of gametic imprinting is at present unknown, although circumstantial evidence suggests it is similar in nature to X inactivation. A model is presented which describes the effects of switching the imprint pattern at male and female target genes. The consequence of such an event is reeproductive isolation, and could lead to the formation of a new species. © 1993 Academic Press Limited.

引用

收藏

页码：1 / 13

页数：13

相关论文

共 64 条

[1] EPIGENETIC CONTROL OF TRANSGENE EXPRESSION AND IMPRINTING BY GENOTYPE-SPECIFIC MODIFIERS [J].

ALLEN, ND ;

NORRIS, ML ;

SURANI, MA .

CELL, 1990, 61 (05) :853-861

[2]

BABINET C, 1990, DEVELOPMENT, P81

[3] THE LOCUS OM, RESPONSIBLE FOR THE DDK SYNDROME, MAPS CLOSE TO SIGJE ON MOUSE CHROMOSOME-11 [J].

BALDACCI, PA ;

RICHOUX, V ;

RENARD, JP ;

GUENET, JL ;

BABINET, C .

MAMMALIAN GENOME, 1992, 2 (02) :100-105

[4] THE MOUSE INSULIN-LIKE GROWTH-FACTOR TYPE-2 RECEPTOR IS IMPRINTED AND CLOSELY LINKED TO THE TME LOCUS [J].

BARLOW, DP ;

STOGER, R ;

HERRMANN, BG ;

SAITO, K ;

SCHWEIFER, N .

NATURE, 1991, 349 (6304) :84-87

[5] PARENTAL IMPRINTING OF THE MOUSE H19 GENE [J].

BARTOLOMEI, MS ;

ZEMEL, S ;

TILGHMAN, SM .

NATURE, 1991, 351 (6322) :153-155

[6]

BEECHEY CV, 1990, MOUSE GENOME, V87, P64

[7] THE MOUSE PINK-EYED DILUTION LOCUS - A MODEL FOR ASPECTS OF PRADER-WILLI SYNDROME, ANGELMAN SYNDROME, AND A FORM OF HYPOMELANOSIS OF ITO [J].

BRILLIANT, MH .

MAMMALIAN GENOME, 1992, 3 (04) :187-191

[8] A GENE FROM THE REGION OF THE HUMAN X-INACTIVATION CENTER IS EXPRESSED EXCLUSIVELY FROM THE INACTIVE X-CHROMOSOME [J].

BROWN, CJ ;

BALLABIO, A ;

RUPERT, JL ;

LAFRENIERE, RG ;

GROMPE, M ;

TONLORENZI, R ;

WILLARD, HF .

NATURE, 1991, 349 (6304) :38-44

[9] ECTOPIC EXPRESSION OF THE H19 GENE IN MICE CAUSES PRENATAL LETHALITY [J].

BRUNKOW, ME ;

TILGHMAN, SM .

GENES & DEVELOPMENT, 1991, 5 (06) :1092-1101

[10] ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION [J].

CAPECCHI, MR .

SCIENCE, 1989, 244 (4910) :1288-1292

← 1 2 3 4 5 6 7 →