CRYSTAL-STRUCTURE AND IN-VITRO ANTITUMOR-ACTIVITY OF DIBUTYLBIS(5-CHLORO-2-HYDROXYBENZOATO)TIN(IV)

The crystal structure of the title compound, [nBu2Sn(5-Cl-2-OH-C6H3CO2)2], shows that in the monomeric species the six-coordinate Sn atom exists in a skew trapezoidal bipyramidal geometry in which the four 0 donor atoms, derived from two asymmetrically chelating carboxylate ligands, define the basal plane and the n-butyl substituents lie over the weaker Sn-O interactions defining a C-Sn-C angle of 147.6(2)-degrees. An unusual feature of the structure is the presence of both intra- and inter-molecular hydrogen bonding contacts which serve to stabilize the structure. The in vitro antitumour activity of this compound against mammary and colon carcinoma cell lines is also reported.