MYOPLASMIC CA2+ CONCENTRATION DURING EXERTIONAL RHABDOMYOLYSIS

被引:48
作者
LOPEZ, JR
ROJAS, B
GONZALEZ, MA
TERZIC, A
机构
[1] HOSP MIL CARLOS ARVELO,DEPT MED INTERNA,CARACAS,VENEZUELA
[2] MAYO CLIN & MAYO FDN,DEPT INTERNAL MED,DIV CARDIOVASC DIS,ROCHESTER,MN 55905
[3] MAYO CLIN & MAYO FDN,DEPT INTERNAL MED,CLIN PHARMACOL UNIT,ROCHESTER,MN 55905
[4] MAYO CLIN & MAYO FDN,DEPT PHARMACOL,ROCHESTER,MN 55905
来源
LANCET | 1995年 / 345卷 / 8947期
关键词
D O I
10.1016/S0140-6736(95)90405-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Exertional rhabdomyolysis can destroy muscle but the pathophysiology is unknown. Using intracellular selective microelectrodes, we found that intracellular Ca2+ concentration ([Ca2+]i) was 1.27 (0.17) mu mol/L (median and interquartile range) in skeletal-muscle biopsy specimens from patients with exertional rhabdomyolysis compared with 0.12 (0.01) mu mol/L in controls. 3 days treatment with dantrolene, a drug that inhibits Ca2+ release from the sarcoplasmic reticulum, decreased [Ca2+]i to 0.22 (0.05) mu mol/L and accelerated patients' recovery. This study demonstrated that exertional rhabdomyolysis is associated with elevated [Ca2+]i, and that dantrolene has a beneficial effect in this syndrome.
引用
收藏
页码:424 / 425
页数:2
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